Shpilman began playing drums at the age of twelve. At the age of 17, he studied composition with Professor Efim Yofe. After ten more years of musical training in Paris and New York, Shpilman founded the Ensemble Moto Perpetuo, a New York-based chamber orchestra specialising in contemporary music and collaborative creations. He was its artistic director from 2011 to 2015. Composer Amir Shpilman is passionate about the physicality of music and brings musicality to every form of expression. He often works with the means of theatre, but also with dancers, visual artists, poets and especially with creative people from non-artistic sectors to realise his musical ideas.

Shpilman has worked in various contexts, including with the Ensemble Intercontemporain (Paris), Ensembles Meitar and Nikel (Tel Aviv), the Gorki Theatre (Berlin), La Biennale di Venezia (Venice), the Jewish Museum (Berlin) and many choirs such as Neue Vocalsolisten (Stuttgart), the choirs of the Staatsoper and Deutsche Oper (Berlin) and AuditivVOKAL (Dresden).